Beta-lactamase production by Haemophilus influenzae confers resistance to penicillin and which other antibiotic?

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Multiple Choice

Beta-lactamase production by Haemophilus influenzae confers resistance to penicillin and which other antibiotic?

Explanation:
Beta-lactamase inactivates beta-lactam antibiotics by hydrolyzing the beta-lactam ring. Haemophilus influenzae that produce this enzyme are resistant not only to penicillin but also to other drugs in the same beta-lactam class, such as ampicillin. The other drugs listed (chloramphenicol, erythromycin, trimethoprim-sulfamethoxazole) are not beta-lactams, so their activity isn’t directly affected by beta-lactamase. Therefore, the other antibiotic rendered ineffective by this mechanism is ampicillin.

Beta-lactamase inactivates beta-lactam antibiotics by hydrolyzing the beta-lactam ring. Haemophilus influenzae that produce this enzyme are resistant not only to penicillin but also to other drugs in the same beta-lactam class, such as ampicillin. The other drugs listed (chloramphenicol, erythromycin, trimethoprim-sulfamethoxazole) are not beta-lactams, so their activity isn’t directly affected by beta-lactamase. Therefore, the other antibiotic rendered ineffective by this mechanism is ampicillin.

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